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In contrast, when a drug's half-life is long, it stays in the body without losing potency for quite some time. Pain tends to return relatively quickly after taking Tylenol or Advil. Over the counter pain relievers have the same half-life problem. Since addiction results from the need to take more medication to keep the effect going, the short half-life can lead to undesirable problems.
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The calm wears off rather quickly, leading to increases in anti-anxiety doses. This is less than ideal for the person who takes them to fight feelings of agitation and create a sense of calm. Unfortunately for those suffering from anxiety, tranquilizers like benzodiazepines (the aforementioned Klonopin, Xanax and Ativan ) are eliminated from the body and reduced in strength quickly.
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The length of a drug's half-life is significant when the medication is used to treat chronic symptoms, or when a patient's body needs to be clear of the drug in order to take the next step in treatment.įor example, some medications are known for having short half-lives, which means the body eliminates them quickly. That sounds good, but, since minimum blood levels of a drug have to be maintained for a medicine to be effective, drugs with shorter half-lives have to be given in more frequent doses.
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HALF LIFE 3 NEVER COMING OUT FULL
That means it takes around 10 days for Klonopin to reach a study state in the blood stream and achieve a full effect-and the same amount of time for the system to be clear of it. Using the longest estimate of Klonopin's half-life, 50 hours, it would be 50 hours times 5 (using the larger of the above half-life estimates), to equal 250 hours or 10.42 days. The presenters use the example of Klonopin (clonazepam), a medication for anxiety. That lengthy stretch is the same amount of time it will take for the drug to be eliminated from the system. The half-life is the amount of time necessary for the concentration of the drug in the bloodstream of the body to be reduced by one-half. The time it will take for a drug to reach a steady state, or full effectiveness, in the system is based on that half-life.Īnd sometimes it just isn't all that fast.Ī presentation from the University of Florida entitled " Basic Biopharmaceutics" clarifies that, "It takes one half-life to reach 50%, 2 half-lives to reach 75%, 3 half-lives to reach 87.5%, 3.3 half-lives to reach 90%, 4 half-lives to reach 93.75% of steady state. In most clinical situations, the attainment of steady state can be assumed after 3-5 half-lives."Īs you can see, two halves do not make a whole. Anyone who has ever popped a cholesterol-lowering drug, or an antidepressant, or an anti-seizure medication, and expected to wake up the next day with a changed life knows that taking medicine is often a waiting game.Īnd anyone who has experienced an adverse side effect from a drug, and is waiting anxiously for it to clear the system, knows the same.īoth the time it will take for a drug to be effective, and the time it will take for it to leave the body completely, depend on a drug's half-life.